How does the C2 CryoBalloon® work?

Cryoablation gets rid of unhealthy, diseased or damaged tissue by freezing it away. For this procedure, the doctor puts a balloon into the esophagus through an endoscope—a medical tube with a camera at its end that goes into the mouth and down towards the stomach—allowing the doctor to reach and see the esophagus.

Once inside the esophagus, the doctor will fill the balloon with air until it touches the sides of the esophagus. Next, the doctor sprays cold nitrous oxide (N2O) into the balloon to freeze the unhealthy cells. The nitrous oxide stays in the balloon, but the unhealthy cells just outside the balloon will freeze and die.

What is Cryoablation?

Cryoablation is a process that applies extreme cold to unwanted human tissue, causing it to freeze and die.

  • Cryoablation works.1-4
  • Patients report they have less pain after cryoablation.1-6
  • Cryoablation removes unhealthy cells without damaging healthy tissue.6-9



Are there current clinical trials for the C2 CryoBalloon®?

C2 Therapeutics is currently enrolling patients to participate in the Coldplay 3 Clinical Trial. Coldplay 3 is further evaluating the effectiveness of the C2 CryoBalloon® Focal Ablation System in patients with Barrett’s esophagus who have not yet received treatment. Previous studies have shown that treatment using the C2 CryoBalloon® has minimal complications and is well-tolerated by patients. 1-6

Who is C2 Therapeutics?

C2 Therapeutics was founded in 2007 to improve eradication methods of soft tissue lesions in endoscopic applications. Headquartered in Redwood City, California, C2 Therapeutics was acquired by Pentax Medical – a division of HOYA Group – in January 2017. The company’s C2 CryoBalloon® Ablation System sets a new standard for simplicity in the ablation of esophageal disease.

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The C2 CryoBalloon® System has been cleared by the U.S. Food and Drug Administration (FDA) and the current Coldplay 3 Trial has been approved by the Institutional Review Board (IRB) at each hospital conducting the procedures.